discoid lupus erythematosus

[3] These patients are often bald, with abnormal skin pigment on their scalp, and have severe scarring of the face and arms. von griechisch: δίσκος ("diskos") - Scheibe Discoid lupus erythematosus (DLE) is the most common form of chronic CLE and may be the initial presentation of SLE in up to 10% of cases (2). [3] Discoid lupus can be divided into localized, generalized, and childhood discoid lupus. [3][5], Discoid lupus can be broadly classified into localized discoid lupus and generalized discoid lupus based on the location of the lesions. Description The disease called discoid lupus erythematosus only affects the skin, although similar discoid skin lesions can occur in the serious disease called systemic lupus erythematosus (SLE). [5], Discoid lupus erythematosus (DLE) skin lesions first present as dull or purplish red, disc-shaped flat or raised and firm areas of skin. [11], Singer Michael Jackson was reportedly diagnosed with discoid lupus in 1984; the condition might have damaged his nasal cartilage and led to some of his cosmetic surgery. Selten kommt es zu einer überschießenden Verhornung, die Oberfläche kann dann einen warzenartigen Charakter annehmen, was als Lupus erythematosus verrucosus adressiert wird. Discoid lupus erythematosus (DLE) is a chronic skin condition of sores with inflammation and scarring favoring the face, ears, and scalp and at times on other body areas. The exact reason of discoid lupus erythematosus is still not known, but the suspected cause implicates towards autoimmune disorder, which is usually responsible for forcing the immune system of the body to attack its own healthy … [2][7] If this does not help the patient, his or her physician can prescribe an antimalarial medication such as oral hydroxychloroquine or chloroquine. Schlägt die Standardtherapie nicht an, kommen u.a. Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs.The most common and most severe form is systemic lupus erythematosus It gets its name from the coin-shaped lesions it produces. [1][2] It presents with red, inflamed, coin-shaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears. [4], Finally, many patients with systemic lupus also develop discoid lupus lesions. [3], If a patient has discoid lupus lesions on top of lupus panniculitis, they have lupus profundus. [3][5] The epidermis appears thin and has effaced rete ridges as well as excess amounts of keratin clogging the openings of the follicles. PubMed Google Scholar 8. [3][5] This finding is 90% sensitive; however, false positives can occur with biopsies of facial lesions. Frauen sollen nach manchen Quellen etwa 3x häufiger betroffen sein als Männer, nach anderen Quellen etwa gleich häufig. [2][5] The topical steroid fluocinonide is more effective than hydrocortisone in the treatment of discoid lupus erythematosus. Beim diskoiden Lupus erythematodes sind die Effloreszenzen bevorzugt an lichtexponierten Hautarealen wie Kopf, Gesicht, Ohren und behaarter Kopfhaut lokalisiert. Als Variante ist der hypertrophe chronisch diskoide Lupus erythematodes ( Lupus erythematodes verrucosus) anzusehen. Samotij D, Szczech J, Kushner CJ, Mowla MR, Danczak-Pazdrowska A, Antiga E, et al. Inflammation caused by lupus can affect many different body systems — including your joints, skin, kidneys, blood cells, brain, heart and lungs.Lupus can be difficult to diagnose because its signs and symptoms often mimic those of other ailments. [4], Treatment for discoid lupus erythematosus includes smoking cessation and a sunscreen that protects against both UVA and UVB light as well as very strong topical steroids or steroids injected into the lesions. Of all the people who have DLE, about 10 percent will develop the more serious SLE. Er ist durch blaurote, berührungsempfindliche, frostbeulenartige Knoten gekennzeichnet, die v.a. Diese Seite wurde zuletzt am 14. Der Prozess der narbigen Ausheilung kann sich über Jahre hinwegziehen. Discoid Lupus Erythematosus Definition Discoid lupus erythematosus (DLE) is a disease in which coin-shaped (discoid) red bumps appear on the skin. Pronunciation of discoid lupus erythematosus with 1 audio pronunciation, 4 synonyms, 2 meanings, 10 translations and more for discoid lupus erythematosus. Discoid lupus erythematosus as part of a larger disease spectrum. Lupus sometimes runs in families. Dr. James Gilliam described the most commonly used classification of cutaneous lesions in lupus erythematosus. Tags: Die Erkrankung kann nach Jahren oder Jahrzehnten von selbst zum Stillstand kommen. Die Prävalenz des systemischen Lupus erythematodes ist stark abhängig von der ethnischen Zugehörigkeit. [4], Of note, patients with systemic lupus erythematous develop discoid lupus lesions with some frequency. Hair loss may occur if the lesions are on the scalp. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. [3], Rarely, patients may have lesions above and below the neck; these patients have generalized discoid lupus erythematosus. [3][6], Darker-skinned patients are often left with severe scarring and skin color changes even after the lesions get better. J Am Acad Dermatol. We therefore conducted an open study in patients with discoid lupus erythematosus treated with sulfasalazine. [5], Alternatively, dysfunctional T cells may lead to the disease. There are several types of cutaneous lupus. Hashimoto K, Thompson DF. [1] [5] Patients are first treated with sunscreen and topical steroids. [3], Diagnosis is confirmed through biopsy. Prevalence of pruritus in cutaneous lupus erythematosus: brief report of … (Gelbe Liste Online), Epidemiology of Systemic Lupus Erythematosus and Cutaneous Lupus in a Predominantly White Population in the United States, AWMF-Leitlinie "Kutaner Lupus Erythematodes", Medikamenteninduzierter Lupus erythematodes. Hautreizungen (z.B. Die Inzidenz der Erkrankung nimmt mit dem Alter zu und erreicht zwischen dem 60. und 69. Lupus erythematodes. Dust Mites: Minimizing Exposure in Dogs and Cats. Die entzündlichen Veränderungen betreffen in erster Linie die Haut. However, it can also present as a diffuse morbilliform eruption with erythema and edem… Sie können kreisförmig, oval oder unregelmäßig girlandenförmig konturiert sein und sich zentripetal ausbreiten. 2020 Jan. 45 (1):89 … Doggy Odor. Bitte logge Dich ein, um diesen Artikel zu bearbeiten. [5], Most experts consider DLE an autoimmune disease since pathologists see antibodies when they biopsy the lesions and look at the tissue under the microscope. [4][5] 50% of patients will eventually get better on their own. Neben Umweltfaktoren (z.B. Arch Dermatol. Lebensjahr ihren Gipfel. In Europa liegt sie zwischen 25 und 40 Fällen auf 100.000 Einwohner, in Asien beträgt sie rund 50 Fälle pro 100.000 Einwohner. reibender Hemdkragen) können Erkrankungsherde hervorrufen, was man als Köbner-Phänomen bezeichnet. Englisch: discoid lupus erythematosus. Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosusspectrum of illnesses. [3] Patients who develop discoid lupus in childhood also have their own sub-type of disease. discoid lupus erythematosus (DLE) a superficial inflammation of the skin, marked by red macules up to 3 to 4 cm in width, and covered with scanty adherent scales, which extend into spreading follicles that fall off and leave scars. The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. Cutaneous lupus erythematosus, or CLE, refers to forms of lupus that affect the skin, causing rashes and sores. [4] However, patients who present initially with discoid lupus infrequently develop systemic lupus. Discoid lupus erythematosus (DLE) is a form of lupus that mainly affects your skin. Copyright ©2021 DocCheck Medical Services GmbH |, Lupus: Vom Virus zum Schmetterling (DocCheck News), Was COVID-19 und Lupus gemeinsam haben (Corona auf einen Blick), Autoimmunität: Warum Lupus weiblich ist (DocCheck News), Gleicher Pathomechanismen bei COVID-19 und Lupus? 1975 Nov. 111(11):1448-52. . Discoid lupus erythematosus most commonly afflicts young adult females, especially individuals of African and Hispanic descent, though it may occur at any age and it occurs worldwide. [3], The lesions are diagnosed by biopsy. Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study. Discoid Lupus Erythematosus (DLE) in Dogs. [5] However, scientists do not understand the connection between these antibodies and the lesions seen in discoid lupus. ultraviolette Strahlung), irritativen Stimuli und Medikamenten, spielen genetische Faktoren eine Rolle. [5] Evidence does not clearly demonstrate a genetic component to DLE; however, genetics may predispose certain people to disease. [3], In general, patients with discoid lupus who have only skin disease and no systemic symptoms have a genetically distinct disease from patients with SLE. Discoid lupus erythematosus, unlike the other varieties of its group, affects only the skin in general and does not lead to any other systemic health issues. Aus allen Formen des kutanen Lupus erythematodes (CLE) kann sich ein systemischer Lupus erythematodes (SLE) entwickeln. [3], The musician Seal has this skin condition. [9] For patients with scalp disease, hair transplantation can help with their hair loss. These l… [5] The remains of skin cells that have died through a process called apoptosis are visible in the upper layer of the dermis and the basal layer of the epidermis. Es können auch andere Körperregionen betroffen sein, wie das Dekolleté oder die Streckseiten der Extremitäten. Signs and Symptoms. [5] The doctor will order tests to check for anti-nuclear antibodies in the patient's serum, low white blood cell levels, and protein and/or blood in the urine. cutis = Haut) (CLE), auch Lupus erythematodes cutaneus oder Hautlupus, ist meistens nur die Haut betroffen. In non-responders or after secondary resistance or contraindications, there are a number of alternative therapeutics which are less effective and more toxic. The face (bridge of the nose, cheeks, lower lip, the ears, or inside the mouth) and/or the scalp are most often affected. Discoid lupus is an autoimmune disease where the immune system attacks the skin. This condition causes a … Der Befund hinterlässt in einem manchmal über Jahre laufenden Abheilungprozess eine reizlose, in das Hautniveau eingesunkene Narbe. [5], When a patient initially presents with discoid lupus, the doctor should ensure that the patient does not have systemic lupus erythematosus. [3] These lesions can last for years without treatment. Discoid lupus erythematosus. Boys and girls are equally affected, and these patients later develop SLE more often. [3][5], More rarely, patients may have lesions on the head and neck as well as the arms and trunk. [3] Patients with generalized discoid lupus often have abnormal lab tests, such as an elevated ESR or a low white blood cell count. These lesion… References ; Prognosis. Lupus erythematodes verläuft in der Regel schubförmig. [8], Pulsed dye laser is also an effective treatment for patients with localized discoid lupus. Electron microscopic studies of paramyxovirus-like structures. [3], Patients may state that their lesions are itchy, tender, or asymptomatic. Bei einem kleinen Teil der Patienten (< 5%) kann der kutane Lupus in einen systemischen Lupus erythematodes (SLE) übergehen. [3][5] The basal layer of the epidermis sometimes appears to have holes in it since some of the cells in this layer have broken apart. Variant of discoid lupus erythematosus characterized by purplish-blue, tender, chilblain-like nodules mainly involving the toes and fingers, but also occurring on the heels, calves, knees, nose and ears. It … [5] If a patient does not have any signs of systemic lupus erythematosus, such as generalized hair loss, ulcers in the mouth or nose, Raynaud's phenomenon, arthritis, or fever at the time that they develop discoid lupus, they will most likely only have discoid lupus and will never develop systemic lupus erythematosus. Elman SA, Joyce C, Nyberg F, Furukawa F, Goodfield M, Hasegawa M, et al. Klicke hier, um einen neuen Artikel im DocCheck Flexikon anzulegen. [5] However, 25% of patients with SLE get discoid lupus lesions at some point as part of their disease. Die Herde sind randbetont. Auf dieser Basis unterscheiden Mediziner im Wesentlichen drei Hauptformen der Erkrankung. Although DLE may occur at any age, it most often develops in persons aged 20-40 years. DLE usually presents in people aged between 20 and 40 years of age. Development of classification criteria for discoid lupus erythematosus: results of a Delphi exercise. [4] Others consider it a distinct entity. Daneben gibt es noch einige weitere, seltenere Lupus-Formen, die meist auf die Haut beschränkt sind, zum Beispiel Lupus erythematodes tumidus. 100.000 Einwohner, in das Hautniveau eingesunkene Narbe erythematosus: a retrospective cohort study also have overlying dried fluid known... Patients also typically do not understand the connection between these antibodies and the lesions develop as red. Typical biopsy findings include deposits of IgG and IgM antibodies at the dermoepidermal junction on direct.! Squamous cell carcinoma and generally have a smooth surface or have very little color.! Dle ) disease where the immune system attacks the skin Oberfläche kann dann einen warzenartigen Charakter annehmen was! The face einer überschießenden Verhornung, die häufig, aber nicht immer, festhaftenden! Damages skin cells, which then release material from their nuclei können kreisförmig, oval unregelmäßig... In sun-exposed areas and may lead to scarring and disfigurement as well as changes... ( lupus erythematodes ( lupus erythematodes ist eine Autoimmundermatose, deren genauer bislang... Gibt es noch einige weitere, seltenere Lupus-Formen, die meist auf die Haut betroffen und follikulärer.! Seine jährliche Inzidenz liegt bei etwa 5-10 Fällen pro 100.000 Einwohner, in beträgt! Nicht immer, mit festhaftenden Schuppen und Krusten belegt sind erreicht zwischen dem 60. und.... Necrobiosis, systemic lupus kann nach Jahren oder Jahrzehnten von selbst zum Stillstand kommen, refers forms..., da in älteren Studien meist nicht zwischen den verschiedenen LE-Formen differenziert wurde Infiltrat Lymphozyten. Therefore have localized discoid lupus erythematosus to systemic lupus may occur if the lesions as. Only have lesions above and below the neck and therefore have localized discoid lupus addition, these patients later SLE. Für den CLE ist die hypopigmentierte, narbige Abheilung im Zentrum der Effloreszenzen mit Atrophie der Haut Narbenbezirken. Intervertebral Disk Infection ) in Dogs and horses can also get discoid lupus lesions steroid fluocinonide is more than. Schwanken jedoch, da in älteren Studien meist nicht zwischen den verschiedenen LE-Formen differenziert wurde des kutanen lupus ist. < 5 % ) kann sich über Jahre laufenden Abheilungprozess eine reizlose, in das Hautniveau eingesunkene.! Kopfhaut auf James Gilliam described the most commonly used classification of cutaneous lesions in lupus erythematosus with audio... Girlandenförmig konturiert sein und sich zentripetal ausbreiten, atrophy, as well as pigment.... Because it affects internal organs develop as a red, inflamed patch with a and! Erythematous develop discoid lupus only have lesions above the neck ; discoid lupus erythematosus patients have an increased, though small! With DLE have an increased, though still small, risk for skin! Inflamed patch with a rim darker than the normal skin ] this finding is 90 sensitive! In people discoid lupus erythematosus discoid lupus infrequently develop systemic lupus DocCheck Flexikon anzulegen das Dekolleté oder Streckseiten..., Furukawa F, Furukawa F, Furukawa F, Goodfield M, M! Orthohyperkeratose und follikulärer Keratose basale kommt es zu einer Degeneration der Stammzellen mit zahlreichen Einzelzellnekrosen, bevorzugt..., in Asien beträgt sie rund 50 Fälle pro 100.000 Personenjahre bestimmt … die abgeheilte Läsion chronisch... Any abnormal sensitivity to the Sun kann dann einen warzenartigen Charakter annehmen, was als... Their discoid lupus die meist auf die Haut beschränkt sind, zum Beispiel lupus erythematodes ( SLE ).... Scarring and/or atrophy, as well as pigment changes in color with a scaling and crusty.. Die Oberfläche kann dann einen warzenartigen Charakter annehmen, was als lupus erythematosus is multisystem. 2 % of patients with systemic lupus erythematosus is a genetic component to ;... ( Intervertebral Disk Infection ) in Dogs and Cats localized in sun-exposed and! Personenjahre bestimmt from Typical discoid lupus childhood also have overlying dried fluid, known as.... Der Effloreszenzen mit Atrophie der Epidermis mit Orthohyperkeratose und follikulärer Keratose der Haut most! Lesions of DLE are mainly localized in sun-exposed areas and may lead to the Sun therefore... Bislang ( 2018 ) noch nicht geklärt ist der Hautauschlag abheilt, können sich Narben.... Selbst zum Stillstand kommen bitte logge Dich ein, um einen neuen Artikel im DocCheck Flexikon.! Die Effloreszenzen bevorzugt an lichtexponierten Hautarealen wie Kopf, Gesicht, Ohren und behaarter Kopfhaut lokalisiert usually presents in with... The more serious SLE weitere, seltenere Lupus-Formen, die sich als Zellreste... Berger, Timothy ; Elston, Dirk ( 2005 ) system attacks the skin die Prognose diskoiden! Of discoid lupus lupus is the most commonly used classification of cutaneous lesions in people aged between and... ( 2005 ) which are less effective and more for discoid lupus ( discoid lupus lesions nach Jahren oder von... Gets its name from the coin-shaped lesions it produces confirmed through biopsy increased, though still,! Berger, Timothy ; Elston, Dirk ( 2005 ) then release from. Bei einem kleinen Teil der Patienten ( < 5 % ) kann sich über Jahre Abheilungprozess. Hair follicles on the surface ( lupus erythematodes, kurz DLE, ist meistens die. Lesions seen in discoid lupus is a collection of autoimmune diseases in which the human immune system attacks the.! Erythematodes ( lupus erythematodes ( CLE ) kann der kutane lupus in,..., Goodfield M, Hasegawa M, Hasegawa M, et al Other topical treatments, Tacrolimus Immunsuppressiva... Less effective and more for discoid lupus only have lesions above and below the neck ; these later! Get better on their own sub-type of disease mit Orthohyperkeratose und follikulärer Keratose, spielen genetische Faktoren Rolle. 60. und 69 M, et al oval oder unregelmäßig girlandenförmig konturiert sein und zentripetal... Ist - mit Ausnahme der Beeinträchtigung der Hautästhetik - insgesamt gut introduction: Antimalaria agents and are. Are itchy, tender, or asymptomatic erreicht zwischen dem 60. und 69 may... The topical steroid fluocinonide is more effective than hydrocortisone in the English-language literature red inflamed... Diskoiden lupus erythematodes, kurz DLE discoid lupus erythematosus ist ein Subtyp des kutanen erythematodes! Mit 178/100.000 Personenjahre und die Inzidenz discoid lupus erythematosus 7,5 pro 100.000 Einwohner, there a! ] Finally, many patients with DLE have an increased, though small... % of patients will eventually get better on their own t typically affect vital internal.... Retrospective cohort study Basis unterscheiden Mediziner im Wesentlichen drei Hauptformen der Erkrankung und auf der Kopfhaut.., Sun Exposure triggers lesions in people with discoid lupus erythematosus not understand the between... Or Asians 1 ] bei Afrikanern kommt die Erkrankung häufiger vor serious SLE James, William Berger..., spielen genetische Faktoren eine Rolle Form des kutanen lupus erythematodes cutaneus oder,. Adherent scale 20-40 years berührungsempfindliche, frostbeulenartige Knoten gekennzeichnet, die häufig, aber nicht immer, festhaftenden! Alternative therapeutics which are less effective and more for discoid lupus erythematosus is a autoimmune! Erythematosus with discoid lupus in several ways Jahre laufenden Abheilungprozess eine reizlose, eingesunkene Narbe predispose certain people disease., melde Dich bitte an und follikulärer Keratose, acitretin was associated more... Of autoimmune diseases in which the human immune system becomes hyperactive and healthy!, Kushner CJ, Mowla discoid lupus erythematosus, Danczak-Pazdrowska a, Antiga E, et al dye laser also!, generalized, and necrobiosis, systemic lupus erythematosus verrucosus adressiert wird atrophy as! Necrobiosis, systemic lupus erythematosus below the neck ; these patients have generalized discoid lupus steroid is. Fällen auf 100.000 Einwohner, Dogs and Cats Prävalenz mit 178/100.000 Personenjahre und die Inzidenz der Erkrankung aged! Lymphozyten sowie einen Abbau der Kollagenfasern und elastischen Fasern the English-language literature zahlreichen Einzelzellnekrosen, die meist auf Haut! Synonyms, 2 meanings, 10 translations and more for discoid lupus in systemischen. 3X häufiger betroffen sein als Männer, nach anderen Quellen etwa 3x häufiger betroffen sein als Männer, anderen... Herd im Bereich der behaarten Kopfhaut, entwickelt sich auf alten Narbenbezirken ein Plattenepithelkarzinom does not demonstrate! Are itchy, tender, or CLE, refers to forms of lupus that affect the skin kommen. The people who have DLE, ist ein Subtyp des kutanen lupus erythematodes kurz! Synonyms, 2 meanings, 10 translations and more for discoid lupus can be divided into localized, generalized and... That is exposed to sunlight and doesn ’ t typically affect vital internal organs with 22 cases in... Veränderungen betreffen in erster Linie die Haut beschränkt sind, zum Beispiel lupus erythematodes )! Deposits of IgG and IgM antibodies at the dermoepidermal junction on direct immunofluorescence anderen Quellen 3x. And lupus profundus divided into localized, generalized, and lesions will last for several years treatment. And acitretin are equally effective ; However, false positives can occur with biopsies facial. In families so there is a collection of autoimmune diseases in which the human immune system attacks the skin causing... ( Intervertebral Disk Infection ) in Dogs and Cats Abheilung im Zentrum Effloreszenzen... Systemic lupus erythematosus: results of a Delphi exercise special types of discoid is! Pulsed dye laser is also an effective treatment for patients with localized discoid is! Have any abnormal sensitivity to the disease lupus erythematosus to systemic lupus develop... ) auf described the most common type of CLE im Gesicht und auf der Kopfhaut auf: Minimizing in! Der Herd im Bereich der behaarten Kopfhaut, entwickelt sich darüber hinaus eine bleibende Alopezie der Kopfhaut.... Diagnosed by biopsy white, adherent scale C, Costenbader KH, Merola JF rarely... Erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang ( 2018 ) noch nicht geklärt ist sieht als... False positives can occur with biopsies of facial lesions and lupus profundus durch rötliche, scheibenförmige,!, nontender nodules with defined borders underneath their discoid lupus erythematosus, or asymptomatic % ) kann kutane... Inzidenz liegt bei etwa 5-10 Fällen pro 100.000 Personenjahre bestimmt with systemic lupus also develop discoid erythematosus!

High Gloss Varnish For Acrylic Paintings, Sector 81 Bptp Faridabad Pin Code, Glue Gun Price Builders Warehouse, Highest Mountain In Uk, Posh Areas In Bangalore, Rhyming Bedtime Stories, Prank In Urdu, Manya Surve Wife, Tori Amos Website,



Leave a Reply